Lenny Freeman is a straight-laced old-school accountant with a dream; to become a famous stand-up comedian. The problem is he's not very funny. Not even close. When his mother dies, leaving him nothing but debt and her '53 Oldsmobile, Lenny hits the road to chase his dream in Vegas and auditioning for Monte Guy's annual "Stand-Up Stand-Off". Along the way (and against his better judgment) Lenny picks up a mysterious traveler named "Hitch" and his trip quickly turns from bad to worse when they stop at a small-town bar. Lenny jumps on stage as a warm-up act, but a run-in with a heckler leads to murder. Now with a dead body in his trunk, Lenny and Hitch are on the run. As the body count piles up, Lenny tries to free himself from his psychotic sidekick and escape to Vegas with the girl of his dreams. But Hitch won't shake so easily. They've got a contract. And the devil is in the details...literally. Not to mention the fact that all this blood and mayhem is having a strange side-effect on...

A white-collar suburban father Kyle (Fran Kranz) who is surprised at his office by long-lost college buddy Zack (Adam Goldberg). Zack is as wild and crazy as ever, brimming with excitement about the self-actualization program he's just finished called Rebirth. He talks Kyle into going on a weekend-long Rebirth retreat,handing over his keys, wallet, and phone. Thus begins his journey down an bizarre rabbit hole of psychodrama, seduction, and violence.

Walter Gary Benjamin works as a ticket-taker slash ticket-tearer at the local Cineplex. When Walter was ten years old he made a deal with God to judge the eternal fate of everyone he comes in contact with in exchange for his father going to Heaven. Walter manages his daily routine and his worrisome mother until the mysterious Greg shows up and forces Walter to confront the meaning of his life, and his future.

Harry Poole, an introverted young man, suffers from bipolar disorder. He enrolls in a clinical trial run by the famous Dr. Lanyon, whose miracle drug is destined to help people like him lead a more balanced life. Under constant video surveillance, Harry quickly experiences positive results and turns into a new man, more charismatic and charming. He even manages to seduce Anna, a young nurse who looks after him. Harry, fully embracing his rebirth, creates a new personality for himself. "Edward Grey" is born, the man he has always wanted to be: outgoing, bold and fearless. Unfortunately, the doctor abruptly discontinues the clinical trial. Cases of rage and confusion have been reported among other test subjects and the medication is pulled. Anna, taking pity, gives Harry a parting gift: a large supply of the pills, with which he continues his own "trial" at home. Intoxicated by the freedom and power of his new identity as "Edward", Harry slowly surrenders himself to his dark alter ego ...